2493-2497
| Ecteinascidin 743: A Minor Groove Alkylator That Bends DNA toward the Major Groove
Maha Zewail-Foote and
Laurence H. Hurley
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2498-2503
| Evaluation of PMF Scoring in Docking Weak Ligands to the FK506 Binding Protein
Ingo Muegge,
Yvonne C. Martin,
Philip J. Hajduk, and
Stephen W. Fesik
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ARTICLES
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2504-2526
| Synthesis and Serotonergic Activity of Substituted 2,N-Benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl)-N,N-dimethyltrypt- amine Derivatives: Novel Antagonists for the Vascular 5-HT1B-like Receptor
Gerard P. Moloney,
Graeme R. Martin,
Neil Mathews,
Aynsley Milne,
Heather Hobbs,
Susan Dodsworth,
Pang Yih Sang,
Cameron Knight,
Marnie Williams,
Miles Maxwell, and
Robert C. Glen
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2527-2534
| Potentiation of cADPR-Induced Ca2+-Release by Methylxanthine Analogues
Rosaria A. Cavallaro,
Luigi Filocamo,
Annamaria Galuppi,
Antony Galione,
Mario Brufani, and
Armando A. Genazzani
[Full Article -
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2535-2541
| 2,3-Dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-trione Derivatives, a Class of Cytotoxic Agents Active on Multidrug-Resistant Cell Lines: Synthesis, Biological Evaluation, and Structure-Activity Relationships
Ippolito Antonini,
Paolo Polucci,
Lloyd R. Kelland,
Ernesto Menta,
Nicoletta Pescalli, and
Sante Martelli
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2542-2560
| Chemical Stability and Fate of the Cytostatic Drug Ifosfamide and Its N-Dechloroethylated Metabolites in Acidic Aqueous Solutions
Véronique Gilard,
Robert Martino,
Myriam Malet-Martino,
Ulf Niemeyer, and
Jörg Pohl
[Full Article -
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2561-2568
| Derivatives of the New Ring System Indolo[1,2-c]benzo[1,2,3]triazine with Potent Antitumor and Antimicrobial Activity
Girolamo Cirrincione,
Anna Maria Almerico,
Paola Barraja,
Patrizia Diana,
Antonino Lauria,
Alessandra Passannanti,
Chiara Musiu,
Alessandra Pani,
Paola Murtas,
Carla Minnei,
M. Elena Marongiu, and
Paolo La Colla
[Full Article -
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2569-2581
| Novel Euglycemic and Hypolipidemic Agents. 4. Pyridyl- and Quinolinyl-Containing Thiazolidinediones
B. B. Lohray,
Vidya Bhushan,
A. Sekar Reddy,
P. Bheema Rao,
N. Jaipal Reddy,
P. Harikishore,
N. Haritha,
Reeba K.Vikramadityan,
Ranjan Chakrabarti,
R. Rajagopalan, and
K. Katneni
[Full Article -
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2582-2587
| Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide Derivatives
Jan Benes,
António Parada,
Anabela A. Figueiredo,
Paula C. Alves,
Ana P. Freitas,
David A. Learmonth,
Rodrigo A. Cunha,
José Garrett, and
Patrício Soares-da-Silva
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2588-2603
| Novel Cryptophycin Antitumor Agents: Synthesis and Cytotoxicity of Fragment "B" Analogues
Vinod F. Patel,
Sherri L. Andis,
Joseph H. Kennedy,
James E. Ray, and
Richard M. Schultz
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2604-2609
| Synthesis and Antimalarial Activity of Cyclic Peroxides, 1,2,4,5,7-Pentoxocanes and 1,2,4,5-Tetroxanes
Hye-Sook Kim,
Yasuharu Shibata,
Yusuke Wataya,
Kaoru Tsuchiya,
Araki Masuyama, and
Masatomo Nojima
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2610-2620
| Phosphinic Pseudo-Tripeptides as Potent Inhibitors of Matrix Metalloproteinases: A Structure-Activity Study
Stamatia Vassiliou,
Artur Mucha,
Philippe Cuniasse,
Dimitris Georgiadis,
Karine Lucet-Levannier,
Fabrice Beau,
Rama Kannan,
Gillian Murphy,
Vera Knäuper,
Marie-Christine Rio,
Paul Basset,
Athanasios Yiotakis, and
Vincent Dive
[Full Article -
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2621-2632
| 1,3-Disubstituted Benzazepines as Novel, Potent, Selective Neuropeptide Y Y1 Receptor Antagonists
Yasushi Murakami,
Hirokazu Hara,
Tetsuo Okada,
Hiroshi Hashizume,
Makoto Kii,
Yasunobu Ishihara,
Michio Ishikawa,
Mayumi Shimamura,
Shin-inchi Mihara,
Goro Kato,
Kohji Hanasaki,
Sanji Hagishita, and
Masafumi Fujimoto
[Full Article -
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2633-2640
 -Functionalized Phosphonylphosphinates: Synthesis and Evaluation as Transcarbamoylase Inhibitors
Alexander Flohr,
Andreas Aemissegger, and
Donald Hilvert
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2641-2650
| Carbonic Anhydrase Inhibitors. Synthesis of Water-Soluble, Topically Effective, Intraocular Pressure-Lowering Aromatic/Heterocyclic Sulfonamides Containing Cationic or Anionic Moieties: Is the Tail More Important than the Ring?
Andrea Scozzafava,
Luca Menabuoni,
Francesco Mincione,
Fabrizio Briganti,
Giovanna Mincione, and
Claudiu T. Supuran
[Full Article - PDF]
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2651-2661
| Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities
Arthur G. Taveras,
Jeff Deskus,
Jianping Chao,
Cynthia J. Vaccaro,
F. George Njoroge,
Bancha Vibulbhan,
Pat Pinto,
Stacy Remiszewski,
Jocelyn del Rosario,
Ronald J. Doll,
Carmen Alvarez,
Tarik Lalwani,
Alan K. Mallams,
Randall R. Rossman,
Adriano Afonso,
Viyyoor M. Girijavallabhan,
Ashit K. Ganguly,
Birendra Pramanik,
Larry Heimark,
W. Robert Bishop,
Lynn Wang,
Paul Kirschmeier,
Linda James,
Donna Carr,
Robert Patton,
Mathew S. Bryant,
Amin A. Nomeir, and
Ming Liu
[Full Article - PDF]
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2662-2672
| Anti-AIDS Agents. 37. Synthesis and Structure-Activity Relationships of (3'R,4'R)-(+)-cis-Khellactone Derivatives as Novel Potent Anti-HIV Agents
Lan Xie,
Yasuo Takeuchi,
L. Mark Cosentino, and
Kuo-Hsiung Lee
[Full Article - PDF]
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2673-2678
Novel Pyrimidine and Purine Derivatives of L-Ascorbic Acid: Synthesis and Biological Evaluation
Silvana Rai -Mali,
Antonija Hergold-Brundi,
Ante Nagl,
Mira Grdi a,
Kreimir Paveli,
Erik De Clercq, and
Mladen Mintas
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2679-2684
| 2,7-Disubstituted Amidofluorenone Derivatives as Inhibitors of Human Telomerase
Philip J. Perry,
Martin A. Read,
Rhian T. Davies,
Sharon M. Gowan,
Anthony P. Reszka,
Alexis A. Wood,
Lloyd R. Kelland, and
Stephen Neidle
[Full Article - PDF]
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2685-2696
| Characterization of "Mini-Nucleotides" as P2X Receptor Agonists in Rat Cardiomyocyte Cultures. An Integrated Synthetic, Biochemical, and Theoretical Study
Bilha Fischer,
Revital Yefidoff,
Dan T. Major,
Irit Rutman-Halili,
Valadimir Shneyvays,
Tova Zinman,
Kenneth A. Jacobson, and
Asher Shainberg
[Full Article - PDF]
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2697-2705
| Effect of Aromatic Short-Chain Analogues of Ceramide on Axonal Growth in Hippocampal Neurons
Ilse Van Overmeire,
Swetlana A. Boldin,
Filip Dumont,
Serge Van Calenbergh,
Guido Slegers,
Denis De Keukeleire,
Anthony H. Futerman, and
Piet Herdewijn
[Full Article - PDF]
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2706-2715
| 1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one: A Selective High-Affinity Antagonist for the Human Dopamine D4 Receptor with Excellent Selectivity over Ion Channels
Robert W. Carling,
Kevin W. Moore,
Christopher R. Moyes,
Elizabeth A. Jones,
Katrine Bonner,
Frances Emms,
Rosemary Marwood,
Shil Patel,
Smita Patel,
Alan E. Fletcher,
Margaret Beer,
Bindi Sohal,
Andrew Pike, and
Paul D. Leeson
[Full Article - PDF]
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2716-2720
| (2R,1'S,2'R,3'S)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the First Potent and Selective Competitive Antagonist of Phospholipase D-Coupled Metabotropic Glutamate Receptors: Asymmetric Synthesis and Preliminary Biological Properties
Roberto Pellicciari,
Maura Marinozzi,
Gabriele Costantino,
Benedetto Natalini,
Flavio Moroni, and
Domenico Pellegrini-Giampietro
[Full Article - PDF]
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